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Diabetes with nerve damage4. Topamax I would like to add a 10th to that: I have broken a nail…can I get Topamax?
Honestly, off-label prescribing has gone too far! Does Topamax really treat so many disparate conditions that doctors prescribe it for everything, even when it is not FDA approved for these conditions?
I must add that Topamax is one of the most dangerous drugs in the prescription market today. Topamax an anticonvulsant under additional name Topiramate generic and in time release Trokendi XR is important to discuss because it was initially formulated as a diet pill.
I have yet to find a single person on this drug who is not seriously considering dropping it due to its adverse effects, not to mention that it does not appear to work as a pain killer. Unfortunately, Topamax is difficult to quit. However, since the voltage dependent calcium channel is a high voltage channel, for some people the discontinuation may end in seizures.
Evidence is also accumulating that Topamax can cause brain damage 4. Personally, I have heard of many cases where it in fact has done just that. Topamax is a sugar substitute that failed as a diet pill but is somehow permitted by the FDA to be used for epileptic seizures. It also received approval for use against migraines.
Adverse effects of Topamax If we look at the list of adverse effects associated with this drug as provided by Wikipedia — Topamaxit is clear that Topamax is not very safe. Indeed, the list is very long. Acute myopia and secondary angle closure glaucoma: Untreated elevated intraocular pressure can lead to permanent visual loss.
These have been reported independent of elevated intraocular pressure.
Monitor decreased sweating and increased body temperature, especially in pediatric patients 5. Baseline and periodic measurement of serum bicarbonate is recommended. Antiepileptic drugs increase the risk of suicidal behavior or ideation 5.
Patients should use caution when operating machinery including automobiles. Depression and mood problems may occur in epilepsy and migraine populations 5. Patients with inborn errors of metabolism or reduced mitochondrial activity may have an increased risk of hyperammonemia. Measure ammonia if encephalopathic symptoms occur 5.
Use with other carbonic anhydrase inhibitors, other drugs causing metabolic acidosis, or in patients on a ketogenic diet should be avoided 5. Yet, I see people being prescribed this drug for all types of off-label use that are unrelated to either seizures or migraines.
The large migraine group I run on Facebook grown to over migraineurs in the past two years. Because I have found that Topamax is the 1 prescribed medicine to migraineurs when they join the group in despair and hopelessness, I have decided to designate Topamax also as the 1 medicine discussed on the series titled drugs of shame.
This is apt because it affects and often damages the neurotransmitters hormones of the brain and thereby puts the whole hormonal structure of the body in chaos. Brain Slowing Topamax may cause brain function slowing.
Topamax is a voltage dependent calcium channel blocker also called voltage-gated calcium channel blockerwhich is a key channel for neuron communication via neurotransmitter release.
This means that neurons that are responsible to organize how the heart beats, how the lungs function, how you blink, and how you digest are all affected by Topamax in a negative way: Many of the side effects of Topamax are so strong that migraineurs who start Topamax stop within weeks some on day 3 of initiating this medication.
The drawing below shows how voltage dependent calcium channels work and what happens when they cannot work because they are blocked. How Voltage Dependent Calcium Channels Work In figure 1 you see a simplified neuron on the left and the axons of another neuron on the right.
In the synaptic cleft normally neurotransmitters work like a domino effect.Which of the following is a properly formatted book citation for an academic report? rutadeltambor.comz, F.A.
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Complexity characterises the behaviour of a system or model whose components interact in multiple ways and follow local rules, meaning there is no reasonable higher instruction to define the various possible interactions.. The term is generally used to characterize something with many parts where those parts interact with each other in multiple ways, culminating in a higher order of emergence.
As mitral valve disease (MVD) progresses in the cavalier King Charles spaniel, and more and more blood backflows (regurgitates) through the mitral valve, the volume overload of blood in the heart stresses the heart's walls and drains the heart of its two main sources of energy -- .
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